|
|
|
| Effect of low molecular weight heparin for treating pregnant women with recurrent abortion after ART and its influence on hormone levels and pregnancy outcomes of women |
| The Third People's Hospital of Haikou City, Hainan Province, 570100 |
|
|
|
|
Abstract To analyze the effect of low molecular weight heparin (LMWH) for treating pregnant women with recurrent abortion after human assisted reproductive technique (ART) ART and its influence on hormone levels and pregnancy outcomes of women. Methods: From January 2013 to December 2017, 120 early pregnant women with recurrent abortion who received ART were selected and divided into control group and observation group according to different treatment methods. The women in control group were treated by routine therapy, and the women in observation group were treated by low molecular weight heparin except to routine therapy. The therapy efficacy of women in both groups was analyzed. Results: Before treatment, there were no significant different in the levels of human chorionic gonadotropin (HCG), progesterone (P), estradiol (E2), D-dimer (D-D), fibrin enzyme activators inhibitor 1 (PAI-1), and fibrinogen of women between the two groups (P>0.05). After treatment, the levels of HCG, P, and E2 of women in observation group were significant higher than those of women in control group (P<0.05), but the levels of DD, PAI-1, and fibrinogen were significant lower than those of women in control group (P<0.05). The rate of full-term pregnancy of women in observation group was significant higher than those of women in control group (P<0.05), but abortion rate was significant lower than that of women in control group (P<0.05). The rate of premature delivery, and incidences of thrombocytopenia, gingival hemorrhage, and ecchymosis and gastrointestinal reaction had no significant different between the two groups (P>0.05). Conclusion: LMWH used for treating pregnant women with recurrent abortion after ART can improve the rate of fullterm pregnancy and reduce abortion rate, and has high safety.
|
|
|
|
|
|
|
|
|
