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| Effect of sequential treatment of chorionic gonadotropin on women with infertility caused by low gonadotropin amenorrhea |
| Central Hospital of Wuhan City, Hubei Province, 430014 |
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Abstract To investigate the effect of sequential treatment of human chorionic gonadotropin on women with infertility caused by low gonadotropin amenorrhea. Methods: 100 patients with infertility caused by low gonadotropin amenorrhea who had accepted routine therapy for 8 years were randomly selected in control group from October 2015 to 2016, and another 100 women with infertility caused by low gonadotropin amenorrhea who had accepted routine therapy combined with sequential treatment of chorionic gonadotropin in the hospital were selected in observation group from September 2016 to June 2017. The efficacy and safety of women were compared between the two groups. Results: There were no significant different in the levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P) and estradiol (E2) of women in the hospital before between the two groups (P>0.05). After treatment in hospital, the number of women in observation group was significant higher than that of women in control group (P<0.05). There were no different in the number of dominant follicles, endometrial thickness, and uterine and ovarian volume of women before between the two groups (P>0.05), but the number of dominant follicles, endometrial thickness, and uterine and ovarian volume of women in the observation group were significant higher than those of women in control group after treatment in hospital (P<0.05). There was no any woman with adverse reaction both in the two groups during the treatment period. The rate of pregnancy successful of women in observation group (88.0%) was significant higher than that (69.0%) of women in control group (P<0.05). Conclusion: Sequential treatment of human chorionic gonadotropin for women with low gonadotropin induced amenorrhea infertility has better efficacy, which can promote rate of pregnancy by improving hormone levels, promote endometrial thickness, uterine and ovarian volume, and the number of dominant follicles of women, so it is one kind of safety and reliable treatment.
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