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| The effect of semen persicaeon endometrium break down of mouse model with physiological menstrual-like |
| National Research Institute for Family Planning, Beijing, 10081 |
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Abstract To study the effect of semen persicae on mouse model with physiological menstruallike. Methods: The pseudopregnant mouse received bilateral ovariectomy after artificial decidualization, whichtriggered progesterone withdrawal, resulted in endometrium break down, and mimiced the physiology of menstruation. Semen persicae was administrated to the mouse model in semen persicae group onlybefore progesterone withdrawal until 24 hours(h) after progesterone withdrawal, and the general morphology and histomorphometry of mousewere observed. Results:At 24h after progesterone withdrawal,the color of mouse uterus insemen persicae group was darker, and the hyperemia was more pronounced, when compared with those of mouse in control group. There was larger number of red blood cells exudation in the break down area of endometrium, as well as the basal layer adjacent to peripheral endometrium, and the red blood cells were widely distributed among endometrial stromal cells, while the above phenomenon were not observed in the control group. Statistical analysis showed that the relative breakdown area and relative hyperemia area ofmouse in semen persicae group were similar to those of mousein control group, but the relative hyperemia area ofmouse in semen persicae group was significant higher that of mouse in control group (P=0.009）. Conclusion: Semen persicaecan promote the exudation of red blood cell in mouse model withphysiologicalmenstrual-like, however its pharmacological effects and functional mechanism need to be further studied.
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