|
Abstract To investigate the value of serum levels of carbohydrate antigen 724 (CA724), cytokeratin 19 fragment (CYFRA21-1) and abnormal prothrombin (PIVKA-II) for diagnosing patients with ovarian cancer. Methods: 46 patients with ovarian cancer were selected in study group, 50 patients with benign ovarian tumor were selected in control group, and 50 healthy women were elected in healthy control group. The levels of serum CA724, CYFRA21-1 and PIVKA-II were detected by chemiluminescence. The area under curve (AUC) of receiver operator characteristic was used for analyzing the value of levels of serum CA724, CYFRA21-1 and PIVKA-II. Results: The levels of serum CA724, CYFRA21-1 and PIVKA-II of patients in study group were the highest among the three groups, but were the lowest in healthy control group (P<0.05).The value of AUC, the sensitivity and the specificity of CA724 level were 0.845, 72.1%, and 87.9%, respectively, the value of AUC, the sensitivity and the specificity of CYFRA21-1 level were 0.813, 67.4%, and 83.5%, respectively, and the value of AUC, the sensitivity and the specificity of PIVKA-II were 0.729, 61.4%, and 91.0%,respectively.The critical value of CYFRA21-1 level was over 24.74 U/L. And the diagnosis positive rates of A724 level combined with CYFRA21-1 level, CA724 level combined with PIVKA-II level, CYFRA21-1 level combined with PIVKA-II level combined detections were 81.6%, 82.6%, and 82.2%,respectively.The sensitivity and accuracy of CA724 level combined with CYFRA21-1 level were higher than those of CA724 level combined with PIVKA-II level or CYFRA21-1 level combined with PIVKA-II level. The sensitivity, positive rate and diagnostic accuracy of the combination of CA724 level, CYFRA21-1 level and PIVKA-II level had increased significantly, while the specificity hadn’t decreased. Conclusion: Serum CA724, CYFRA21-1 and PIVKA-II levels have high value for diagnosing ovarian cancer, and the combination of the Serum CA724, CYFRA21-1 and PIVKA-II levels can increase the positive rate of ovarian cancer diagnosed significantly.
|
|
|
|
|
|
