Abstract To investigate the effect of mode and timing of termination pregnancy on maternal and infant outcomes of patients with early onset severe preeclampsia. Methods: 68 patients with early onset severe preeclampsia were selected as the study objects, and were divided in group A (30 patients, terminated pregnancy <32 gestational weeks), group B (27patients, terminated pregnancy form 32 to 33 gestational weeks) , and group (C 29 patients, terminated pregnancy≥34 gestational weeks) according to the time of termination of pregnancy. Then retrospective analyzed the patients in the three groups on their delivery methods, serious complications, perinatal outcomes and so on. Results: The gestational weeks of onset severe preeclampsia and the delivery gestational weeks of patients in group A were the shortest, and those of patients in group C were the longest. The expected treatment time of patients in group B was significant longer than that of patients in other two groups (P<0.05), and there was no significant different in the expected treatment time of patients between group A and group C (P>0.05). There was no significant different in the incidence of complication among the three groups (P>0.05). The average birth weight of newborns in group A was (1128.6±110.6) g, which was significant lower than that (1718.5 g±151.7 g) in group B, and that in group B was significant lower than that (2206±233.9 g) in group C (P<0.05). The incidence of perinatal mortality and neonatal asphyxia in group A were highest among the three groups (P<0.05), but which had no significant different between group B and group C (P>0.05). The incidence of fetal distress, perinatal death, and neonatal asphyxia of patients with cesarean section were significant lower than those of patients with vaginal delivery among the three groups (P<0.05). Conclusion: Patients with early onset severe preeclampsia should terminate pregnancy at 34 gestational weeks, which has better maternal and child outcomes. Reasonable cesarean section can reduce perinatal mortality and neonatal asphyxia.
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