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Abstract To inveterate the influence of early nutrition intervention on glycolipid metabolism and fetal outcome of pregnant women with high risk factors of gestational diabetes mellitus (GDM). Methods: 264 pregnant women with high risk factors of GDM from January to June 2017 were enrolled, 102 women underwent early nutrition interventions were in observation group, and 162 women with nonearly nutrition intervention were in control group. The incidence of GDM and other complications during pregnancy and neonatal outcomes were compared between the two groups. The levels of fasting blood glucose (FBG), postprandial 2h blood glucose (2h PG), glycosylated hemoglobin (HbAlc), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) of all women were detected before and after intervention. Results: The levels of FBG, 2hPG, HbAlc and TG of women in observation group were significant lower than those of women in control group (P<0.05), there were no significant different in levels of serum TC, LDL-C and HDL-C between the two groups (P>0.05). The gestational weight gain (GWG) and neonatal body weight in observation group were significant lower than those of women in control group (P<0.05). The incidences of GDM, cesarean section rate and macrosomia of women in observation group were 14.7%, 27.5% and 2.4%, respectively, which were significant lower than those of women (25.3%, 44.4% and 14.2%, respectively )in control group (P<0.05). There were no significant different in the incidence of other complications or adverse outcomes of maternal and child between the two groups (P>0.05). Conclusion: Early nutrition intervention can effectively improve the glycolipid metabolism of pregnant women with high risk factors of GDM, reduce the incidence of GDM, and improve pregnancy outcomes, and is benefit for the fetal outcomes.
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