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Abstract Objective: To explore the value of ultrasonography for evaluating the risk of macrosomia during the third trimister pregnancy (28-32 gestational weeks). Methods: The data of 256 full-term newborns were retrospective analyzed, and the included newborns were divided into macrosomia group and normal group according to their birth weight. The relationship between ultrasound detection results during 28-32 gestational weeks and fetal weight was analyzed, and the best critical value for the diagnosis of macrosomia during the third trimister pregnancy was explored. Results: The maternal weight gain during pregnancy in macrosomia group was significant higher than that of mother in normal group (P<0.05). Compared to those in the normal group, the biparietal diameter (BPD), head circumference (HC), abdominal circumferences (AC), femoral length (FL) and Z-scores of AC of fetus in the macrosomia group were significant higher (P<0.05). the values of BPD, HC, AC, FL and Z-score of AC of fetus were positively correlated with fetal weight(r=0.411, 0.502, 0.757, 0.682, and 0.802). The Z-score of AC of fetus had the closest relationship with fetal weight, then the values of AC and FL had the second closest relationship with fetal weight, while values of BPD and HC of fetus had less relative with fetal weight. The ROC curve showed that the area under the curve of Z-score of AC and AC value of fetus was larger, and the Yoden index was higher. The optimal critical Z-score of AC and value of AC of fetus were 1.241 and 269.42 mm, respectively. The optimal critical value of FL of fetus was 57.04 mm, with the highest specificity (85.64%). The sensitivity (83.36%) combined with the specificity (80.7%) of Z-score of fetus for evaluating the risk of macrosomia was better than that of AC of fetus. Conclusion: The values of AC, HC and FL of fetus were measured by ultrasonography during 28-32 gestational weeks are closely related to the occurrence of macrosomia. Z-score of AC (>1.241), ACvalue (>269.42 mm) and FL value (>57.04 mm) have high value for predicting the occurrence of macrosomia.
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