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| Expression of placental growth factor of pregnant women with early-onset severe preeclampsia and its relationship with pregnancy outcomes |
| Baodi District People's Hospital, Tianjin, 301800 |
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Abstract Objective: To explore the expression of placental growth factor (PIGF) of pregnant women with early-onset severe preeclampsia (SPE), and to study its relationship with pregnancy outcomes. Methods: 80 pregnant women with early-onset SPE were enrolled in observation group and 100 normal pregnant women were in control group from January 2017 to December 2018. On the delivery day, the plasma PIGF level of women in both groups was detected, and clinically relevant indexes of women in both groups were observed. The relationship between PIGF level of women in observation group and their pregnancy outcomes was analyzed. Results: The plasma PIGF level of women in the observation group were significant lower than that of women in the control group, but the values of SBP, DBP and S/D of women in the observation group were significant higher (P<0.05).The abnormal rate of plasma PIGF level of women in the observation group was 51.3%. The neonatal gestational weeks of birth, birth weight, placental weight, and 1 min Apgar score of pregnant women with abnormal PIGF level were significant lower than those of pregnant women with normal PIGF level (P<0.05), while values of LAC and umbilical artery S/D of pregnant women with abnormal PIGF level were significant higher (P<0.05). Correlation analysis showed that the expression level of PIGF of pregnant women with early-onset SPE were negatively correlated with the values of SBP, DBP and umbilical artery S/D, while were positively correlated with neonatal birth weight and 1 min Apgar score (P<0.05). Conclusion: The expression level of PIGF of pregnant woman with earlyonset SPE is closely related to pregnancy outcomes. The PIGF level of pregnant women has some clinical value for predicting pregnancy outcomes, so it should be more focused on.
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