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| Value of serum biochemical markers combined with ultrasound for prenatal screening fetal Down syndrome |
| Affiliated Hospital of Yan'an University, Yan'an, Shaanxi Province, 716000 |
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Abstract Objective: To explore the value of serum biochemical markers combined with ultrasound for prenatal screening fetal Down syndrome (DS). Methods: The data of 4001 pregnant women from January 2017 to June 2019 were collected, and all these included women were examined by serum biochemical markers combined with ultrasound for prenatal screening fetal DS. Results: 6 fetuses of women in these 4001 pregnant women had been clinically diagnosed DS during the first tremister pregnancy. The serum levels of free human chorionic gonadotropin β(freeβ-hCG) and fetal nuchal translucec (NT) value by ultrasound of women with DS fetus were significant higher than those of women without DS fetus, but the serum pregnancy-related plasma protein A(PAPP-A) level of women with DS fetus was significant lower (P<0.05). The sensitivity, specificity and coincidence rate of serum biochemical markers levels for screening DS were 66.7%, 99.6% and 99.6%, respectively. The sensitivity, specificity, and coincidence rate of ultrasonic for screening DS were 83.3%, 99.6% and 99.5%, respectively. The sensitivity, specificity and coincidence rate of serum biochemical markers levels combined with ultrasonic for screening DS were 83.3%, 99.9%, and 99.8%, respectively. The specificity and coincidence rate of serum biochemical markers levels combined with ultrasonic for screening DS were signifficant higher than those of serum biochemical markers levels or ultrasound for screening DS alone (P<0.05). Conclusion: Serum biochemical markers levels and ultrasound are both important methods for screening DS during the first tremister pregnancy, but the combination screening can improve the efficacy of screening DS.
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