|
|
|
| Effect and mechanism of compound salvia miltiorrhiza injection combined with magnesium sulfate on TLR4 level of women with early onset severe preeclampsia |
| Baoding Maternal and Child Health Care Hospital, Hebei Province, 071000 |
|
|
|
|
Abstract Objective: To investigate the effects and related mechanism of compound salvia miltiorrhiza injection combined with magnesium sulfate on Toll-like receptor 4 (TLR4) level, vascular endothelial function, and immune factors of women with early onset severe preeclampsia (EOSPE). Methods: 118 pregnant women diagnosed as EOSPE were selected from September 2016 to January 2019 and were divided in the study group and the control group (59 cases in each group) by random number method. On the basis of routine treatment, the women in the control group were treated with magnesium sulfate, and the women in the study group were treated with magnesium sulfate combined with compound prescription salvia miltiorrhiza injection for 2 weeks. The levels of serum TLR4, vascular cell adhesion molecule-1 (VCAM-1), endothelin-1 (ET-1), nitric oxide (NO), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor (TNF), interleukin-6 (IL-6) and other immune cytokines of all women in two groups were detected before and after treatment. Results: The level of TLR-4 of women in the study group and the control group were 3.14±0.89g/L and 3.86±1.05g/L, which all had decreased after treatment, and the levels of VCAM-1 and ET-1, TNF and IL-6 had also decreased significantly, while the levels of NO and TGF-beta 1 had significantly increased. Conclusion: Compound salvia miltiorrhiza injection combined with magnesium sulfate can significantly improve vascular endothelial function and immune inflammation of women with early onset severe preeclampsia, and can also down-regulate the expression of TLR-4 of women.
|
|
|
|
|
|
|
|
|
