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| A multi center randomized trial of China and WHO recommended medical abortion regimen for termination of pregnancy up to 49 gestational days |
| National Center for Women and Children’s Health, China CDC, Bejing, 100081 |
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Abstract Objective: To compare the efficacy, safety and acceptability between China-recommended regimen and WHO-recommended regimen for termination of pregnancy up to 49 gestational days. Methods：Women aged 18-40 who requested termination of pregnancy up to 49 gestational days in 4 public hospitals from Beijing and Qiqihar’er were divided into 2 groups randomly, and the women received China-recommended regimen were in group A and the women received WHOrecommended regimen were in group B. All the women were accepted drugs administered and followed up according to the protocol of China or WHOrecommended regimen. Results：The complete abortion rate of women in group A was 87.7%, which was significant lower than that (81.3%) of women in group B (χ2=5.699，P<0.05) . The average day of vaginal bleeding of women after abortion in group A was 13.9 days, which was significant longer than that (11.8 days) of women in group B (t=2.956, P<0.01). There were no severe side-effects occurrence in both groups, and the rates of general side-effects, such as nausea, fatigue and low abdominal pain had no significant different between the two groups. The proportion of satisfactory, acceptability for side-effects, possibility to choose the regimen again, or recommending to others of women in group B had much higher. Conclusion：Comparing to that of China-recommended regimen, WHOrecommended regimen had more efficacy in termination of pregnancy up to 49 gestational days, but the safety is similar in the two regimens.
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