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| The value of beta-HCG, CA125, P and IGF-II levels for predicting the outcomes of women with threatened abortion |
| Central Hospital of Xinxiang City, Henan Province, 453000 |
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Abstract Objective: To explore the value of the levels of serum β-human chorionic gonadotropin (β-HCG), glycoprotein 125 (CA125), progesterone (P) and insulin-like growth factor-II (IGF-II) for predicting the outcomes of women with threatened abortion. Methods: 120 pregnant women with threatened abortion were selected in study group, and 240 normal pregnant women were selected in the control group. The serum levels of β-HCG, CA125, P and IGF-II of women at 6-8 gestional weeks were compared between the two groups. The women in the study group were further divided study group 1 (women with continuing pregnancy) and study group 2 (women with abortion) based on outcomes after treatment.The receiver operating curve (ROC) was used to analyze the value of the four indicators for predicting the pregnancy outcomes of all women. Results: The serum levels of β-HCG, P and IGF-II of women in the study group were significant lower than those of women in the control group, but the serum CA125 level was significant higher (P<0.05). After treatment, the serum levels of β-HCG, P and IGF-II of women in the study group 2 were significant lower than those of women in the study group 1, but the serum CA125 level was significant higher (P<0.05). The sensitivity, the specificity, and the area under the curve (AUC) of β-HCG level for predicting adverse outcomes was 87.2%, 76.4%, and 0.825, respectively. The sensitivity, the specificity, and the AUC of CA125 level for predicting adverse outcomes was 73.3%, 65.2%, and 0.704, respectively. The sensitivity, the specificity, and AUC of P level for predicting adverse pregnancy outcomes was 86.8%, 74.0%, and 0.821, respectively. The sensitivity, the specificity, and AUC of IGF-II level for predicting adverse outcomes was 53.3%, 61.44%, and 0.579, respectively. Conclusion: The levels of serum β-HCG, CA125, P and IGF-II of women with threatened abortion change significantly, and the levels of serum β-HCG, CA125, P have certain clinical value for predicting the adverse pregnancy outcomes of women with threatened abortion.
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