|
|
|
| The levels of KiSS-1 and Bcl-2 in placenta tissues of women with severe preeclampsia and their correlation with perinatal outcomes |
| Jiangning Hospital Affilitiated to Nanjing Medical University, jiangsu Province, 211100 |
|
|
|
|
Abstract Objective: To study the relationship between the levels of metastasis suppressor gene-1 (KiSS-1) and B lymphocyte tumor-2 gene (Bcl-2) in placenta tissues of pregannat women and their severe preeclampsia situation and pregnancy outcomes. Methods: 60 pregannat women with severe preeclampsia who had experinced cesarean section from January 2017 to June 2018 were randomly selected in experimental group, and 30 normal pregnant women who had also experinced cesarean section were randomly selected in control group during the same period. Maternal placenta tissues of all included women were collected immediately after delivery. RT-PCR, Western blot, and immunohistochemical methods were used to detect the levels of KiSS-1 and Bcl-2 in placenta tissues. The levels of KiSS-1 and Bcl-2, perinatal outcomes of women were compared between the two groups. And the relationship between the levels of KiSS-1 and Bcl-2 in placenta tissues and the perinatal outcomes was analyzed. Results: The relative absorbance of KISS-1/beta-actin and Bcl-2 /beta-actin, and the positive expression rates of KiSS-1 and Bcl-2 of women in the experimental group were significant higher than thoe of women in the control group (P<0.05). The incidences of fetal distress, intrauterine growth restriction, neonatal asphyxia, premature infants, and low birth weight infants in the experimental group were significant higher than those in the control group, but the neonatal weight and Apgar score were significant lower (P<0.05). There were no significant different in perinatal mortality between the two groups (P>0.05). The expressions of KiSS-1 and Bcl-2 in placenta tissues were negatively correlated with neonatal asphyxia rate, neonatal weight, and Apgar score (P<0.05). Conclusion: The expression levels of KiSS-1 and Bcl-2 in placenta are closely related to severe preeclampsia and perinatal outcomes, which maybe have a new idea for preventing and treating women with pregnancy induced hypertension.
|
|
|
|
|
|
|
|
|
