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| The influence of laparoscopic myomectomy on the of immunity function, angiogenesis situation, and levels of matrix metalloproteinases and related hormone levels of women with uterine fibroids |
| Gongan County Hospital of Traditional Chinese Medicine, Jingzhou, Hubei Province, 434300 |
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Abstract Objective: To explore the influence of laparoscopic myomectomy on on the of immunity function, angiogenesis situation, and levels of matrix metalloproteinases 2 and 9 (MMP-2and MMP-9) and related hormone levels of women with uterine fibroids. Methods: 96 women with uterine fibroids were selected as study subjects, and were divided into control group and observation group (48 cases in each group) according to different surgical methods from October 2015 to September 2017. The levels of immunoglobulin (IgA, IgG and IgM), matrix metalloproteinase, angiogenesis situation, and related hormone levels of women were detected before and after operation. Results: After operation, the levels of IgA, IgG and IgM of all women in the two groups had no significantly difference (P>0.05), and those of women in the control group were significant lower than those of women in the observation group (P<0.05). The levels of MMP-2 and MMP-9 of all included women had significantly decrease after operation (P<0.05), and the levels of MMP-2 and MMP-9 of women in the observation group were significant lower than those of women in the control group (P<0.05). After operation, the levels of VEGF, EGF and VEGFR2 of women in the observation group had no significant difference (P>0.05), but those of women in the control group had significantly increased (P<0.05). After operation, the levels of Cor, NE, FSH and E2 of women in the observation group had no significant difference (P>0.05), but levels of Cor, NE, FSH of women in the control group had significantly increased, while E2 level of women in the control group had significantly decreased (P<0.05). Conclusion: Laparoscopic myomectomy can effectively decrease the immunosuppressive effect, inhibit the expression of MMP and the proliferation and differentiation of related vascular cells in tumor tissues, can alleviate the stress injury, which can contribute to the recovery of ovarian function.
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