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| The expression of serum Galectin-1 and Galectin-3 of pregnant women with severe preeclampsia, and its relationship with placental abruption |
| Ganzi Tibetan Autonomous Prefecture People's Hospital,Sichuan Province,626000 |
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Abstract Objective: To investigate the expressions of serum Galectin-1 and Galectin-3 of pregnant women with severe preeclampsia, and to explore its relationship with placental abruption. Methods: 70 pregnant women with severe preeclampsia were selected in study group, and 56 healthy pregnant women were selected into control group from August 2016 to October 2017. Women in the study group were divided into study group 1 (25 cases) and study group 2 (45 cases) according to whether placental abruption occurred. Enzymelinked immunosorbent assay (ELISA) was used to detect serum Galectin-1 and Galectin-3 levels of all included women. The values of serum Galectin-1 and Galectin-3 levels were analyzed by ROC. Logistic multivariate regression analysis was used to analyze the related factors affecting placental abruption of women with severe preeclampsia. Results: The levels of serum Galectin-1 and Galectin-3 of women in the study group were significant higher than those of women in the control group (P<0.05). The sensitivity, the specificity, and the cut-off values of Galectin-1 level for diagnosing severe preeclampsia were 74.29%, 98.21%, and 34.61ng/L, respectively. And the sensitivity, the specificity, and the cut-off values of Galectin-3 level for diagnosing severe preeclampsia were 85.71%, 78.57%, and 26.33 ng/L, respectively. The levels of serum Galectin-1 and Galectin-3 of women in the study group 1 were significant higher than those of women in the study group 2 (P<0.05). Logistic analysis showed that levels of serum Galectin-1 and Galectin-3 were independent risk factors for placental abruption of women with severe preeclampsia. Conclusion: The expression levels of Galectin-1 and Galectin-3 in serum of women with severe preeclampsia are high, both of which are closely correlated with placental abruption, and they may play an important role in placental abruption of women with severe preeclampsia.
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