|
Abstract Objective: To study the changes and significance of the levels of peripheral blood monocyte chemoattractant protein-1 (MCP-1), soluble vascular endothelial growth factor receptor-1 (sFlt-1) and Soluble cell adhesion molecule-1 (sICAM-1) of women with endometriosis. Methods: 60 women with endometriosis were selected in the study group from November 2016 to November 2018, and other 60 healthy childbearing age women were selected into the control group during the same period. The expression of peripheral blood MCP-1, sFlt-1 and sICAM-1 of women were compared between the two groups, and the changes and significance of the levels of peripheral blood MCP-1, sFlt-1 and sICAM-1 of women in both groups were analyzed. Results: The levels of peripheral blood MCP-1, sFlt-1, and sICAM-1 of women in the study group were 38.94±4.10 ng/ml, 231.92±23.42 pg/ml, and 349.53±32.40 ng/ml, respectively, which were significant higher than those (11.32±1.54 ng/ml, 95.34±14.17, and 212.01±25.93ng/ml) of patients in the control group（P<0.05）. The levels of MCP-1, sFlt-1 and sICAM-1 of women with endometriosis III-IV stage were significant higher than those of patients with I-II stage (P<0.05). Pearson single factor analysis showed that MCP-1 level was positively correlated with levels of sFlt-1 and sICAM-1 (P<0.05), and sFlt-1 level and were also positively correlated with sICAM-1 level (P<0.05). The AUC of MCP-1, sflt-10, and sICAM-1 levels for diagnosing endometriosis were 0.788, 0.798, and 0.759, respectively. The AUC of the MCP-1 level combined with sflt-10 level and sICAM-1 level was 0.934, which was significant higher than that of MCP-1 level, sflt-10 level, or sICAM-1 level only. The specificity and accuracy of MCP-1 level combined with sflt-10 level and sICAM-1 level for diagnosing endometriosis were 90.34% and 92.10%, which were significant higher than those of MCP-1 level, sflt-10 level, or sICAM-1 level only (P<0.05). Conclusion: The expressions of peripheral blood MCP-1, sFlt-1 and sICAM-1 of patients with endometriosis increase significantly, which involve in the occurrence and development of endometriosis. The level of peripheral blood MCP-1 combined with sflt-10 level and sICAM-1 level can serve as a reliable index for diagnosing and predicting prognosis of women with endometriosis.
|
|
|
|
|
|
