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Abstract Objective: To explore the relationship between level of serum antimullerian hormone(AMH) and age or level of sex hormones of childbearing age women. Methods: In the retrospective study, dates of 719 childbearing age women from Guigang city people’s hospital were collected, which included level of serum AMH, follicle stimulating hormone(FSH), luteinising hormone(LH), testosterone(T), estradiol (E), and progesterone(P). All recruited women were divided into two groups based on their age (from 38 to 45 years old in elder group, and from 23 to 37 years old in control group). The level of serum parameters of included women by the mannwhitney test were compared between the two groups. The relationship was analyzed by spearman rank correlation coefficient method between serum AMH and age or level of sex hormones of women in the two groups. Results: The level of serum FSH of women in elder group were significant higher than that of women in control group (P<0.01), the level of AMH, E, P and T of women in elder group were significant lower than those of women in control group (P<0.01), but there were no significant different in the level of LH between the two groups（P>0.05）. The levels of serum AMH was negatively correlated with age and FSH（P<0.01）, and was positively associated with P（P<0.05）in both groups. The level of serum AMH was positively associated with LH and T（P<0.01）, but was no significant correlation with E（P>0.05）in control group. The level of serum AMH was negatively correlated with LH（P<0.01）, and was positively correlated with E（P<0.01）, but was no significant correlation with T（P>0.05）in elder group. Conclusion: The level of serum AMH of women is gradually declined with age. The level of serum AMH decreasing (begins from 30 years old) can reflect the decline of female fertility early when compared to that the level of serum FSH (begins from 38 years old). The correlation between serum AMH and FSH, LH or E2 of women at 3845 years old is more close than that of women in 2337 years old.
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