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Abstract Objective: To explore the effect of Dvl2 on AngⅡinduced cardiomyocyte hypertrophy. Methods: The expression of Dvl2 in AngⅡtreated cardiomyocytes for 48 h was detected by Western Blot. Rat primary cardiomyocytes were infected with recombinant adenovirus AdGFP or AdDvl2 for 24 h and then treated by AngⅡ for 48 h. After AngⅡ treatment, cardiomyocyte area was detected by immunofluorescence analysis. The expression of cardiac hypertrophy marker (βMHC) and hypertrophyrelated signaling pathway were detected by Western Blot. Results: The expression of Dvl2 was increased in AngⅡtreated cardiomyocytes. Compared with the control group, AdDvl2 infection enhanced AngⅡinduced cardiomyocyte hypertrophy and increased the expression of βMHC. Moreover, overexpression of Dvl2 increased the phosphorylated level of AKT. Conclusion: Dvl2 can enhance AngⅡinduced cardiomyocyte hypertrophy, and its mechanism may be associated with the activation of AKT.
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