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| Effects of different doses of levothyroxine tablets on thyroid function and pregnancy outcome of pregnant women with hypothyroidism |
| Zhengzhou People's Hospital of Henan Province, Zhengzhou, Henan |
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Abstract Objective: To investigate the effect of different doses of levothyroxine tablets on thyroid function and pregnancy outcome of pregnant women with hypothyroidism. Methods: 120 pregnant women with hypothyroidism were selected in this study, and among them, 80 pregnant women were randomized divided into high dose group and low dose group (doses of levothyroxine tablets: 75ug/d vs. 50ug/d，100ug/d vs.75ug/d，125ug/d 100ug/d) by random number table. Other 40 pregnant women without given any drug except given diet treatment were in control group. The changes of thyroid function indexes of women before and after treatment in three groups were detected, and rate of complications and pregnancy outcome were compared among the three groups. The neonatal development scale (BSID) was used to assess neonatal development at 6 months after birth, which included intelligence development index (MDI) and motor development index (PDI). Results: After treatment, the level of TSH and TPOAb of women in the three groups decreased significantly (P<0.05). The decreased degree of TSH, TPOAb level of women in high dose group was significantly better than that of women in low dose group, and the decreased degree of TSH, TPOAb level of women in low dose group was significantly better than that of women in control group (P<0.05). The score of BSID, MDI and PDI of newborns in high dose group were significantly higher than those of newborns in low dose group, and the score of BSID, MDI and PDI of newborns in low dose group were significantly higher than those of newborns in control group (P<0.05). The rate of hypertension and cholestasis of women in the high dose group and low dose group were similar to those of women in control group (P>0.05), but the rate of abnormal glucose metabolism of women in high dose group and low dose group was significantly lower than that of women in control group (P>0.05). The rate of cesarean section, neonatal asphyxia, neonatal malformation and fetal death in high dose group and low dose group had no significant difference when compared to those of women in control group (P>0.05). The rate of extremely low body weight of infants in high dose group and low dose group was significantly lower than that in control group (P<0.05), and the rate of extremely low body weight of infants in high dose group was also significantly lower than that in low dose group(P<0.05). Conclusion: levothyroxine tablet can significantly improve the thyroid function and pregnancy outcome of pregnant women with hypothyroidism, and the effect of high dose of levothyroxine is better than that of low dose of levothyroxine.
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