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Abstract Objective: To investigate the relationship between the side effects of subcutaneous implantation of progesterone and peripheral blood hormones or inflammatory factors. Methods: 105 patients underwent subcutaneous implantation of progesterone were followed up. The main side effects of subcutaneous implantation of progesterone were observed. The levels of estradiol (E2), testosterone (T), testosterone (T), Interleukin2 (IL2) and tumor necrosis factor alpha (TNFα) were detected before and after implanted. Results: The main side effects were changes of vaginal bleeding pattern and facial acne. In the first 90 days and the second 90 days, peripheral blood E2 of patients with different bleeding patterns had significantly reduced (P<0.05), T, IL2 And TNFα had significantly increased(P <0.05). Conclusion: Changes of vaginal bleeding patterns and facial acne are primary side effects of progesterone subcutaneous implantation, which effects the use of progesterone subcutaneous implantation continually. So the preoperative counseling service should be strengthened, and the compliance of women's use should be improved. Relevant mechanism research should be conducted for reducing the occurrence of side reaction and developing an effective treatment.
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