Abstract Objective: To investigate the clinical efficacy of fentanyl combined with ropivacaine for epidural anesthesia in painless labor and its influence on labor process. Methods:116 parturients were randomly divided into control group and observation group (58 cases in each group). The parturients in the two groups were all treated with epidural anesthesia, the parturients in control group were injected 0.1% ropivacaine after the puncture, and the parturients in observation group were injected a mixture of 0.5 g/ml of fentanyl and 0.1% ropivacaine. The anesthetic effect, the changes of main index of parturients, and situation of labor were compared between the two groups. Results:The anesthesia excellent rate (94.8%) of parturients in observation group was significant higher than that of parturients in control group (81%). The time of the first stage of labor (6.1±2.1h, 1.7±0.4h) of parturients in observation group was significant shorter than that of parturients in control group (7.8±2.3h, 2.4±0.6h). The time of anesthesia onset (4.3±1.2min), block time (1.8±0.9 min) and duration (5.3±1.6 min ) of parturients in observation group were significant better than those of parturients in control group (13.6±2.5 min, 24.6±2.8 min, 2.5±0.6 min, respectively) (P< 0.05). But bleeding valume of parturients in observation group (198.6±40.8ml) had no significant difference when that compared to parturients in control group (195.2±41.7ml) (P>0.05). The neonatal weight in observation group (4.25±1.64kg) had also no significant difference when compared to control group (4.18±1.59kg) (P>0.05). The incidence of neonatal asphyxia (5.2%) and the incidence of fetal distress (5.2%) in observation group were significant lower than those of parturients in control group (12.1% and 13.8%) (P < 0.05). Conclusion: Fentanyl combined with ropivacaine for epidural anesthesia in painless labor can improve the anesthetic effect and can shorten the labor process, which has good clinical significance.
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