|
Abstract Objective: To investigate the changes of sex hormone and insulin levels of childbearing age women with PCOS and hyperandrogenemia, and to provide evidences for clinical diagnosis and treatment of women with PCOS who had menstrual disorder, infertility, or other symptoms. Methods: 200 women with PCOS and hyperandrogenemia in Tianjin central obstetrics and gynecology hospital from September 2011 to August 2014 were included in PCOS group, and 200 healthy women were recruited in control group during the same period. The serum levels of testerone (T), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), Pesterone (P), fasting insulin (FINS) of all included women were detected by electrochemiluminescence immunoassay, and fasting plasma glucose (FPG) level was measured by glucose-oxidase method. The insulin resistance was calculated through the homeostasis model assessment (HOMA-IR). Results: Among 200 women in PCOS group, 81% women had hyperinsulinemia, 85.4% women had insulin resistance, and 42% women had hyperluteinemia. Compared with those of women in control group, the serum levels of T, E2, LH, LH/FSH radio, FINS and HOMA-IR of women in PCOS group were significant higher (P<0.05). Conclusion: Women with PCOS and hyperandrogenemia have hormonal disorders, such as hyperinsulinemia, insulin resistance, and hyperluteinemia. In order to reduce the pain of patients and to decrease the incidence of disease, it is important to monitor hormone levels, and to treat for alleviating the clinical symptoms and improving patients' endocrine environment.
|
|
|
|
|
|
