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| The value of serum levels of testosterone, SHBG, CRP and BTP during the second trimester and the third trimester pregnancy for predicting pregnancy induced hypertension |
| Jiangbei Campus, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210000 |
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Abstract Objective: To investigate the value of serum testosterone (T), sex hormone binding globulin (SHBG), C-reactive protein (CRP), and beta trace protein (BTP) during the second trimester and the third trimester pregnancy for predicting pregnancy induced hypertension. Methods: 60 pregnant women with pregnancy induced hypertension in Zhongda hospital affiliated to Southeast university were included in study group, and 60 healthy pregnant women were in control group. The serum levels of T, SHBG, CRP and BTP of all included pregnant women during the second trimester and the third trimester pregnancy were detected, and were compared between the two groups. The predictive value of serum levels of T, SHBG, CRP or BTP for pregnancy induced hypertension was analyzed. Results: There were no significant different in serum levels of T and CRP between the two groups (P>0.05). The serum SHBG level of pregnant women in study group were significant lower than that of pregnant women in control group (P<0.05). The serum BTP level of pregnant women in study group was significant higher than that of pregnant women in control group (P<0.05). In pregnant women of study group, the BTP levels of pregnant women with proteinuria during the second trimester and the third trimester pregnancy were significant higher than those of pregnant women without proteinuria, but the SHBG levels were significant lower than those of pregnant women without proteinuria (P<0.05). The levels SHBG and BTP of pregnant women in study group were positively correlated with gestational weeks, level of SHBG was negatively correlated with SBP and DBP, and level of BTP was positively correlated with SBP and DBP (P<0.05). The critical value of SHBG for diagnosing pregnancy induced hypertension was 376.3ng/ml, and its sensitivity and specificity was 90.5% and 88.6%, respectively. The critical value of BTP for diagnosing pregnancy induced hypertension was 322.4ng/ml, and its sensitivity and specificity was 92.4% and 89.5%, respectively. Conclusion: The serum levels of T and CRP are no significant correlation with the occurrence of pregnancy induced hypertension during the second trimester and the third trimester pregnancy. The serum levels of SHGB and BTP are significantly correlated with the occurrence of pregnancy induced hypertension, and have higher sensitivity and specificity for diagnosing pregnancy induced hypertension, which have good predictive value for pregnancy induced hypertension.
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