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| Predictive value of vitamin D deficiency in gestational diabetes mellitus in early pregnancy and its effect on pregnancy outcome |
| 1. The Fifth Central Hospital of Tianjin, Tianjin, 300450；2. School of Public Health, Medical University Of Tianji |
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Abstract Objective to investigate the predictive value of vitamin D25 (OH) D3] deficiency in early pregnancy on gestational diabetes mellitus (GDM) and its effect on pregnancy outcome. Methods: Methods 80 cases of early pregnant women who were regularly tested in our hospital from January 2015 to October 2017 were selected as the subjects. The levels of 25 (OH) D3 and blood glucose were detected respectively. According to the level of 25 (OH) D3, the subjects were divided into vitamin D sufficient group (39 cases), vitamin D deficiency group (20 cases) and vitamin D deficiency group (21 cases). According to the blood glucose level, the subjects were divided into GDM group and non GDM group. The difference of different 25 (OH) D3 level group GDM and the incidence of bad pregnancy outcome was analyzed, Logistic regression analysis 25 (OH) deficient. The relationship between the lack of GDM and the outcome of bad pregnancy. Results: The levels of 25(OH)D3 in pregnant women and women in GDM group were (14.02±3.25) ng/ml] and (13.77±3.05) ng/ml], respectively, lower than those in normal pregnant women (P<0.05). The incidences of vitamin D deficiency and GDM deficiency were 45.00% and 61.90%, respectively, which were higher than those in the vitamin D sufficient group. The differences were statistically significant (P<0.05). The incidence of miscarriage, premature delivery, and fetal distress in the vitamin D deficient group were 38.10%, 33.33%, and 28.57%, respectively, which were significantly higher than those in the vitamin D-sufficient group. The differences were statistically significant (P<0.05). Vitamin D deficiency group There was no difference with the vitamin D sufficient group (P>0.05). The OR of GDM in pregnant women with serum 25(OH)D 3<20ng/ml in early pregnancy and second trimester was 3.828 (95%CI:1.398-10.95) and 6.201 (95%CI:1.692-20.86) respectively. In early pregnancy,25(OH)D3<20ng/ml of pregnant women who suffered miscarriage, premature delivery, and fetal distress were found to have an OR of 1.482（95%CI：1.120-4.352）、1.771（95%CI：1.135-3.035）、1.350（95%CI：1.251-6.325）. Conclusion: Deficiency and lack of 25(OH)D 3 in GDM pregnant women, lack of 25(OH)D 3 and lack of GDM were associated with the occurrence of GDM and adverse pregnancy outcomes. Detection of 25(OH)D 3 predicts the occurrence of GDM and adverse pregnancy outcomes.
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