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Abstract Objective:To investigate the correlation of body mass index (BMI) of women before and during pregnancy with the glucose and lipid metabolism of women at later pregnant stage and pregnancy outcomes. Methods: The data of 1520 pregnant women in Baoji maternal and child health care hospital were collected and analyzed retrospectively. All included women were divided into normal BMI gourp, high BMI group, or low BMI group according to the BMI of women before pregnancy. The weight gain of women during pregnancy was statistical analyzed, and the mode of delivery, neonatal status, rates of pregnancy complications and adverse pregnancy outcomes were also analyzed. Results: The incidences of pregnancy-induced hypertension, gestational diabetes mellitus (GDM), premature rupture of membranes, placental abruption, fetal distress and premature birth of women in high BMI group were significant higher than those of women in the other two groups (P<0.05). The cesarean section rate of women in high BMI group or in low BMI group was significantly higher than that of women in normal BMI group. The Apgar score of newborns in high BMI group or in low BMI group was significant lower than that of newborns in normal BMI group, and the rate of newborns in high BMI group or in low BMI group transferred to NICU was significant higher than that of newborns in normal BMI group (P<0.05). In normal BMI group and high BMI group, the incidence of pregnancy-induced hypertension, GDM, premature rupture of membranes, placental abruption, fetal distress, premature delivery, cesarean section, and newborns transferred to NICU of women with BMI increased fast during pregnancy were significant higher than those of women with BMI increased appropriately, and the neonatal Apgar score of women with BMI increased fast during pregnancy was significant lower than that of women with BMI increased appropriately (P<0.05). In low BMI group, there were no significant different in the incidence of pregnancy-induced hypertension, GDM, premature rupture of membranes, placental abruption, fetal distress, premature delivery, cesarean section, newborns transferred to NICU, and the neonatal Apgar score between women with BMI increased fast during pregnancy and women with BMI increased appropriately (P>0.05). The levels of TG and FPG, the value of pre-pregnancy BMI, and the weight gain during pregnancy of women with GDM were significant higher than those of women withot GDM (P<0.05). There was a positive correlation between weight gain during pregnancy and the levels of TG and FPG during the third trimester pregnancy (P<0.05). Conclusion: Prepregnancy and pregnancy BMI values are closely related to the levels of glucose and lipid metabolism and pregnancy outcomes of women during the third trimester pregancy. Pre-pregnancy high BMI and excessive weight gain during pregnancy will increase the risk of abnormal glucose and lipid metabolism, and maybe increase the rates pregnancy complications, caesarean section, and adverse pregnancy outcomes.
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