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| Efficacy of low dose progesterone Injection combined with Xiaoyao pill for treating women with threatened abortion |
| 1.The People's Liberation Army no. 98 Hospital, Huzhou, Zhejiang Province, 313000；2.Chaozhou Maternity Hospital of Guangdong Province |
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Abstract Objective:To explore the effect of low dose progesterone injection combined with Xiaoyao pill for treating pregnant women with threatened abortion. Methods: 90 women with threatened abortion in the people's liberation army no. 98 hospital from January 2015 to January 2017 were selected and divided into observation group and control group (45 cases in each group) according to the random digital table method. In addition to routine treatment such as rest and given folic acid and vitamin E, the women in control group were intramuscularly injected low dose progesterone (10mg, 1 times /d, 14 days). The women in observation group were given Xiaoyao pill (8 pills per time, 3 times /d, 14 days) except intramuscularly injected low dose progesterone and routine treatment. The levels of serum human chorionic gonadotropin (β-HCG), progesterone (P), estradiol (E2) and cancerantigen 125 (CA125) were measured in 1 and 2 weeks during treatment, and symptom scores were calculated, and curative effect were evaluated after treatment, and adverse reactions during treatment were recorded. Results: The levels of serum β-HCG, P and E2 of women in observation group were signifficant higher than those of women in control group in 1 and 2 weeks during treatment, and the level of CA125 of women in observation group was signifficant lower than that of women in control group (P<0.05). After the treatment, the scores of symptoms and physical signs of women in observation group were signifficant less than those of women in control group, and the overall effacy of women in observation group was better than that of of women in control group (P<0.05). During treatment, dizziness, headache, fatigue, urticaria, nausea and vomiting, and breast swelling had been found in some women, but there were no significant different in the incidence of above adverse reactions between the two groups (P>0.05). Conclusion: For women with threatened abortion, low doses of progesterone intramuscular injection combined with oral Xiaoyao pill can improve the rate of tocolytic successful, and it has high safety.
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