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Abstract Objective:To explore the effect of different dosage of methoxamine in spinal combined with epidural anesthesia of cesarean section. Methods: 136 pregnant women wanted delivery by cesarean section were randomly divided into group A, group B, group C, and group D (34 cases in each group). The women in group A, group B, group C were given 2, 4 and 6 mg methoxamine,repectively (methoxamine added into 20 mL normal saline, and were infused at the speeds of 0.1, 0.2 and 0.3 mg/min immediately after lumbar puncture success). The women in group D were infused 20ml physiological saline. The systolic blood pressures (SBP), diastolic blood pressures (DBP), heart rate (HR), and pulse oxygen saturation (SPO2) of all women were recorded when entered the operating room, 1 and 5 min after spinal anesthesia, 1 min before delivery, and 5 min after delivery. The incidences of adverse reactions of women included hypotension, nausea and vomiting, and bradycardia were observed during operation. The neonatal Apgar score and umbilical vein blood gas indexes were recorded. Results: SBP of all women in the four groups in T1, T2 and T5 were significant lower than those in T0 (P<0.05). SBP of women in group A, B and C in T3 were significant lower than those in T2 (P<0.05). HR of women in group A and D in T1 were significant higher than those in T0 (P<0.05), and HR of women in group C in T1 were significant lower than that in T0 (P<0.05), but there was no significant different in HR between T1 and T0 (P>0.05). The incidence of hypotension of women in group A, group B, or group C was significant lower than those of women in group D (P<0.05). The incidence of nausea of women in group B was significant lower than those of women in group D (P<0.05). The incidence of bradycardia of women in group C was significant higher than that of women in group D (P<0.05). There was no significant different in blood gas indexes and Apgar score of newborns at 1, 5 min after born among the four groups (P>0.05). Conclusion: Prophylactic methoxamine infused by micropump at the speed of 0.2 mg/min after spinal anesthesia during cesarean section is effective for preventing hypotension, and can make maternal hemodynamic fluctuations more stable.
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