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| The relationship between inflammatory factors, oxidative stress of pregnant women with gestational diabetes mellitus and their insulin resistance |
| The Fifth Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang |
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Abstract Objective: To explore the relationship between inflammatory factors, oxidative stress of pregnant women with gestational diabetes mellitus (GDM) and their insulin resistance. Methods: From January 2017 to December 2017, 66 pregnant women with GDM in the fifth hospital affiliated to Xinjiang medical university were selected into observation group, and 60 normal pregnant women during the same period were selected into control group. All included women were detected their fasting blood glucose (FBG), fasting insulin (FINS), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and C Dialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and total antioxidant capacity (TAOC). And insulin resistance index (HOMA-IR) of all women was calculated. Results: The levels of FBG, FINS, HOMA-IR IL-6, TNF-α and hs-CRP, and MDA of women in observation group were significant higher than those of women in control group (P<0.05), but the levels of SOD, GSH, and TAOC of women in observation group were significant lower than those of women in control group (P<005).In observation group, there was positive correlation between level of IL-6, TNF-α, hs-CRP or MDA and HOMAIR (P<0.05), but there was negative correlation between HOMA-IR and level of SOD, GSH, or TAOC (P<0.05). Conclusion: The levels of inflammatory factors and oxidative stress of pregnant women with GDM are closely related to their insulin resistance.
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