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| The correlation between serum slox-1 or HCG and pregnancy outcomes of pregnant women with pregnant induced hypertension |
| 1.Jurong People's Hospital of Jiangsu Province, Jiangsu Province, 212400；2.Nanjing Gulou Hospital |
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Abstract Objective: To investigate the correlation between serum soluble lectin-like oxidized low density lipoprotein receptor-1 (sLOX-1) or human chorionic gonadotropin (β-hCG) and pregnancy outcomes of pregnant women with pregnant induced hypertension. Methods: 68 pregnant women with pregnant induced hypertension in Jurong people's hospital of Jiangsu province were selected into observation group. During the same period, another 68 healthy pregnant women who had received normal prenatal examination were selected into control group. Enzyme-linked immunosorbent assay (ELISA) was used for measuring serum sLOX-1 concentration , chemiluminescence assay was used to detect serum β-hCG levels of all included pregnant women. And the level of serum sLOX-1 or β-hCG related to adverse outcomes of pregnant women were compared between the two groups. Results: The levels of serum sLOX-1and β-hCG pregnant women in observation group were significant higher than those of pregnant women in control group (P<0.05). The levels of serum sLOX-1 and β-hCG of pregnant women with severe pregnancy-induced hypertension were significant higher than those of pregnant women with moderate pregnancy- induce hypertension, and those of pregnant women with moderate pregnancy induced hypertension were significant higher than those of pregnant women with mild pregnancy induced hypertension (P<0.05). The pearson correlation analysis had showed that there was a positive correlation between levels of serum sLOX-1 and β-hCG with pregnancy-induced hypertension (r=0.742, P=0.000). The level of serum sLOX-1 of pregnant women in observation group was positively correlated with pregnancy induced hypertension, premature delivery, fetal distress, premature rupture of membranes, and fetal growth restriction (P<0.05). The level ofβ-hCG of pregnant women in observation group was positive correlated with pregnancy induced hypertension, fetal distress and fetal growth restriction (P<0.05), but was not correlated with preterm labor and premature rupture of membranes (P>0.05). Conclusion: The levels of serum sLOX-1 and β-hCG of pregnant women with pregnancy induced hypertension increase are associated with adverse pregnancy outcomes. In clinical practice, the adverse pregnancy outcomes of pregnant women with pregnancy induced hypertension maybe predicted by detecting serum sLOX-1and β-hCG levels.
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