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Abstract Objective: To observe the influence of methyldopa combined with labetalol for treating pregnant women with preeclampsia on the blood pressure control and expression of serum LIF and Apelin. Methods：100 pregnant women with preeclampsia in maternal and child health care hospital of Jiyuan city from February 2016 to April 2017 were selected and divided into control group and study group randomly (50 cases in each group). The women in control group were received routine treatment, while the women in observation group were treated by methyldopa combined with labetalol on the basis of routine treatment. The clinical efficacy was observed after 7 days of treatment. Results：The clinical effective rate of women in observation group (90.0%) was significant higher than that of women in control group (76.0%)（χ2=4.710，P=0.029）. The effect of blood pressure control of women in observation group was significant better than that of women in control group, and the amount of 24h urine protein of women in observation group was significant lower than that of women in control group (P<0.05), and the expression of serum LIF and Apelin women in in observation group was significant lower than that women in control group (P<0.05), and the incidence of adverse reactions of women had no significant different between the two groups (P>0.05).Conclusion：Methyldopa combined with labetalol for treating pregnant women with preeclampsia can effectively control the blood pressure, can regulate serum LIF and Apelin levels. And it has perfect effectiveness and safety, so it is worthy of clinical application.
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