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| The expression of PBX3 in cervical carcinoma tissue and its relationships with clinicopathological features and prognosis |
| Maternal and Child Health Care Hospital, Liuzhou City, Guangxi Zhuang Autonomous Region |
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Abstract Objective: To investigate the expression of preleukemia transcription factor 3 (PBX3) in cervical carcinoma tissue, and to analyze its relationships with clinicopathological features and prognosis. Methods: The cervical carcinoma and para cancerous tissues of 82 women were collected. The expression of PBX3 protein in these tissues was detected by Western blot and immunohistochemistry. The relationships of different tissues with the clinicopathological features and prognosis were analyzed. COX regression was performed for analysis the clinical factors which might be affected the survival of patients. All women were followedup for 30 months, and their survival rates were analyzed by KaplanMeier, and the difference of survival of women between the two groups was detected by LogRank method. Results: Compared with those in para cancerous tissue, the positive expression rate of PBX3 protein in cervical cancer tissues was significant higher (P< 0.05). The expression of PBX3 protein was not related to age, pathological type or depth of tumor invasion (P>0.05), but which was related to tumor staging, tumor differentiation, tumor diameter, and infiltration degree lymph node metastasis (P<0.05). In the 3 year followup, there was 30 people died, and the mortality rate was 36.59%. COX multivariate analysis showed that tumor staging, tumor differentiation, tumor diameter, lymph node metastasis and PBX3 were independent factors affected the prognosis of the patients. 18 cases died in PBX3 positive expression group, and 12 cases died in PBX3 negative expression group. KaplanMeier survival curve showed that there was significant difference in KaplanMeier survival curve between the two groups (P<0.05). Conclusion: The upregulated expression of PBX3 in cervical carcinoma is related to the stage of tumor, degree of differentiation, lymph node metastasis and so on, so it may be a biological indicator of the prognosis of cervical cancer patients.
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