|
Abstract Objective: To explore the feasibility of dihydromorphinone hydrochloride combined with ropivacaine mesylate used for epidural anesthesia in cesarean section. Methods: 100 women with cesarean section were randomly divided into two groups, 50 women in control group were given epidural anaesthesia by dihydromorphinone hydrochloride, and 50 women in study group were given epidural anaesthesia by dihydromorphinone hydrochloride combined with ropivacaine mesylate. The pain scores at the end of operation, 4h after operation, 8h after operation, 12h after operation, or 24h after operation were compared between the two groups, and the levels of serum inflammatory factors of all women were detected before operation, and 4, 12, 24 or 48h after operation, the incidences of postoperative adverse reaction of women in both groups were statistically analyzed. Results: The scores of visual analogue scale (VAS) at 4, 8 or 12h after operation of women in study group were significant lower than those of women in control group (P<0.05). The levels of serum tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10) and interleukin-6 (IL-6) of women in study group at 4, 12, 24 or 48h after operation were significant lower than those of women in control group (P<0.5). There were no significant difference in the incidence of vomiting, pruritus, drowsiness, urinary retention, and the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: It is safety and effective of dihydromorphinone hydrochloride combined with ropivacaine mesylate used for epidural anesthesia in cesarean section.
|
|
|
|
|
|
