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| Cervical medicine preparation for the removal of intrauterine devices of menopausal women |
| Peking Union Medical College Graduate School, National Research Institute for Family Planning, Beijing, 100081 |
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Abstract This review aims to understand the medicine regimen and clinical effects of common medicine for cervical preparation before IUD removal of postmenopausal women in China. Multiple electronic databases which including CNKI and Wanfang Database was searched systematically. Reference lists of articles published in Chinese between 1978 and 2017 were searched and 207 articles were included. The medicines used for cervical preparation are divided into three categories: estrogens, prostaglandins and tibolone. The top three medicines mentioned in the literature were misoprostol, estradiol valerate and nilestriol, for the literature number of 75, 51 and 38. In control trails, although the dose and duration of treatment are different, effects of cervical dilatation are obvious, and the successful removal rates are high. It is noteworthy that most researches don’t design rigorous enough, the sample sizes are not sufficient, and the observation indicators are not uniform or incomplete, so that the results obtained are not reliable and can only be used as a reference. It is recommended that a rigorously designed multi-center, large-sample clinical study should be conducted in the future to provide high level of evidence for the identification of effective cervical drug preparation solution.
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