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| Expression and clinical significance of HMGB1, Notch1 and PCNA in cervical cancer tissues |
| 1.Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan City, Hubei Province, 430030；2.Taihe Hospital of Shiyan City in Hubei Province |
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Abstract Objective: To investigate the expression and clinical significance of high mobility group protein B1 (HMGB1), human transmembrane protein Notch1, and proliferating cell nuclear antigen (PCNA) in cervical cancer tissues. Methods: From Jan. 2015 to Jan. 2018, cervix tissues specimens of 60 patients who were diagnosed as cervical squamous cell carcinoma and treated by operation were collected. At the same period, cervix tissues specimens of 40 patients who were diagnosed with cervical intraepithelial neoplasia (CIN) stage III, and other cervix tissues specimens of 20 healthy volunteers were also collected. The expression of HMGB1, Notch1 and PCNA in different cervix tissues specimens were detected by immunohistochemical method. And the difference and correlation of 3 cytokines expression in cervical tissues with different clinicopathological features were explored. Results: The positive expression rates of HMGB1, Notch1 and PCNA in cervix tissues of patients with CIN stage III were significant lower than those of patients with cervical cancer, but were significant higher than those of health women (P<0.05). In the patients with cervical cancer, the positive expressions of HMGB1, Notch1 and PCNA were the highest in cervical tissues of patients with low differentiation and high clinical pathological stage (TNM). And the expressions of HMGB1, Notch1 and PCNA were positively correlated (P<0.05). Conclusion: The expression of HMGB1, Notch1 and PCNA increased in cervical cancer tissues, and the degree of expression of HMGB1, Notch1 and PCNA is increasing as the cervical cancer cells become more poor differentiated degree and the TNM stage increases.
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