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| Analysis of the levels of serum uric acid and lactate dehydrogenase of pregnant women with hypertensive disorder complicating pregnancy |
1. The Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000;
2. Zhao Ge Zhuang Hospital of Kailuan General Hospital |
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Abstract Objective: To investigate the levels of serum uric acid (UA) and lactate dehydrogenase (LDH) of women with hypertensive disorder complicating pregnancy (HDCP), and to analyze their significances. Methods：80 women with pre-eclampsia who had been hospitalized in the affiliated hospital of north China university of science and technology from October 2016 to April 2018 were selected into observation group, which were divided into mild pre-eclampsia group (n=25) and severe preeclampsia group (n=55) according to the severity of pre-eclampsia. And the women with severe pre-eclampsia were also divided into early onset severe pre-eclampsia group (n=23) and late onset severe pre-eclampsia group (n=32). Another 80 normal pregnant women were selected in control group. The serum levels of UA and LDH of women were compared between observation group and control group, and the serum levels of UA and LDH of women with different types of preeclampsia were also compared. Results：Serum UA and LDH levels of women in observation group were significant higher than those of women in control group (P<0.05). Compared with those of women with mild pre-eclampsia, the levels of serum UA and LDH of women with severe pre-eclampsia were significant higher (P<0.05). Compared with those of women with early onset severe preeclampsia, the levels of serum UA and LDH of women with late onset of severe pre-eclampsia were significant higher (P<0.05). Furthermore, with the pre-eclampsia aggravated, the incidence of perinatal adverse outcomes had increased, and there was a significant difference in perinatal adverse outcomes among normal pregnant women, women with mild preeclampsia, and women with severe pre-eclampsia (P < 0.05). Conclusion：Serum levels of UA and LDH will increase following the pre-eclampsia aggravating, so serum levels of UA and LDH maybe monitoring indicators of the changes in condition of women with HDCP.
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