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| Influence of the changes of umbilical artery blood flow parameters on pregnancy outcomes of pregnant women with gestational diabetes mellitus |
| Yuhuan People's Hospital of Zhejiang Province, Zhejiang |
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Abstract Objective: To observe the influence of changes of umbilical artery blood flow parameters on pregnancy outcomes of pregnant women with gestational diabetes mellitus (GDM). Methods: 120 pregnant women with GDM who had accepted antenatal examination and had confirmed the diagnosis of GDM in Yuhuan people's hospital of Zhejiang province were selected in observation group, and another 120 healthy pregnant women at the same time were in control group from December 2015 to February 2017. The umbilical artery blood flow related parameters (PI, RI and S/D) of all pregnant women were measured at 1820 gestational weeks, and the pregnancy outcomes were observed in both groups, and the correlation between the umbilical artery blood flow parameters and the adverse pregnancy outcomes of pregnant women with GDM was analyzed. Results: The value of PI, RI and S/D of women in observation group were significant higher than those of women in control group (P<0.05). The incidence of adverse pregnancy outcomes and the rate of cesarean section of women with abnormal umbilical artery blood flow parameters were significant higher than those with normal umbilical artery (79.7% vs. 21.7%,χ2=39.036, P=0.000) and (66.2% vs 26.1%,χ2=18.277, P=0.000). The incidence of neonatal hypoglycemia, puerperium infection and postpartum hemorrhage of women with abnormal umbilical artery blood flow parameters were significant higher than those with normal umbilical artery blood flow (16.2% vs 8.7%,χ2=5.79, P=0.016). The umbilical artery blood flow PI, RI and S/D were positively correlated with the incidence of adverse pregnancy outcomes (r=0.90, 0.78, 0.83; P=0.000, 0.016, 0.004). Conclusion: At 18-20 gestational weeks, the umbilical artery blood flow PI, RI and S/D of pregnant women with GDM are higher than those of healthy pregnant women, which have positive correlation with the adverse pregnancy outcomes. These indexes maybe have predictive value on the occurrence of GDM and the adverse pregnancy outcomes, so they should be paid more attention to in obstetrics clinical.
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