|
|
|
| Preliminary study on the effect of mifepristone followed by diffferent regimens of misoprostol for termination of pregnancy between 8 and 16 weeks of gestation |
| 1.Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011; 2. Peking University People’s Hospital; 3. Beijing ChaoYang Hospital of Capital Medical University; 4. Peking University Third Hospital; 5. Peking University First Hospital |
|
|
|
|
Abstract Objective: To explore the efficacy and safety of mifepristone combined with different regimens of misoprostol to terminate pregnancy at 8-16 weeks of gestation. Methods: 120 women were recruited and randomized to receive 200mg mifepristone orally (100 mg of mifepristone at the first and the second day, respectively), then they were given six different regimens of misoprostol after taken the first mifepristone 36 hours later. The outcome measures were the rate of successful abortion, induction to abortion interval, the amount of vaginal bleeding and the adverse events. Results: There were no significant differences in the rate of successful abortion (from 90% to 100%, P=0.465) and induction to abortion intervals (from 4.2h to 9.5h, P=0.253) among the groups. The rate of successful abortion after first dose of misoprostol of women in vaginal groups was significantly higher than that of women in oral groups. The average amount of bleeding after placenta expulsion was 67.4ml within 2h and 37.7ml between 2h and 24h. The emergency curettage rate was 11.8%. There were no serious adverse events（SAE）, the adverse events（AE）related to drugs were mild or moderate, and there were no statistical significant different (P=0.686) in the study. The overall satisfaction rate was 84.6%. Conclusion: This preliminary result of the study may suggest different regimens of misoprostol combined with mifepristone are all effective and safe to terminate pregnancy at 8-16 weeks of gestation. Yet, the sample size should be expanded to explore the optimal regimen.
|
|
|
|
|
|
|
|
|
