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| Evaluation of p16/Ki67 dual-stained cytology for detecting cervical precancerous disease |
| Department of Obsterics and Gynecology, Peking University Third Hospital, Beijing |
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Abstract Objective: To evaluate the clinical application of p16/Ki67 dual staining in the diagnosis of cervical precancerous disease. Methods: A total of 92 women who were screened at Peking University Third Hospital from January 2017 to May 2017 were recruited in this study. The sensitivity, specificity, positive and negative likelihood ratio, and the area under the ROC curve (AUC)in the detection of ≥CIN2 lesions were compared among the p16 / Ki67dualstaining, TCT and HRHPV for detecting cervical precancerous disease. The clinical value of p16/Ki67 dual staining was further evaluated for the identification of ≥ CIN2 lesions in women with positive HRHPV or elder than 30 years old. Results: For detection of ≥ CIN2 lesions, p16/Ki67 dualstaining had similar sensitivity when compared with TCT and HRHPV (86.36% vs 84.85% vs 92.42%, P=1.000, P=0.424), and specificity was significant higher than TCT and HRHPV (76.92 vs 30.77% vs 26.92%, P=0.001, P=0.001), AUC was also higher than TCT and HRHPV (0.816 vs 0.578 vs 0.597, P=0.001, P<0.001). Similar patterns were observed in the subgroup of women with positive HRHPV or over than 30 years old. Conclusion: p16 / Ki67dualstaining can improve the specificity of diagnosing ≥CIN2 lesions, and has good clinical application value.
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