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| Clinical observation of Baotai decoction combined with low dose of dydrogesterone for treating pregnant women with threatened abortion caused by luteal phase defect |
| Anji County Traditional Chinese Medicine Hospital of Zhejiang Province |
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Abstract Objective: To observe the clinical efficacy of Baotai decoction combined with low dose of dydrogesterone for treating pregnant women with threatened abortion caused by luteal phase defect. Methods: 138 pregnant women with threatened abortion caused by luteal phase defect in Anji county traditional chinese medicine hospital from June 2014 to June 2016 were randomly divided into two groups, which included study group (n=69) and control group (n=69). Pregnant women in control group were treated by routine dose of dydrogesterone therapy, and pregnant women in study group were treated by Baotai decoction combined with low dose dydrogesterone. The level of serum progesterone (P) and human chorionic gonadotropin (HCG) of pregnant women were compared between the two groups after treatment. The time of bleeding stop, and time of abdominal and backache pain remission of included women were compared between the two groups. The rate of adverse effects of drugs were recorded during treatment. The success rate of tocolytic theraphy, birth weight of newborn, and rate of preterm birth were also analyzed. Results: The level of serum P and HCG of women in study group were significantly higher than those of women in control group (P<0.05). The time of vaginal bleeding stop, and time of abdominal and backache pain remission of women in study group were significantly shorter than those of women in control group. The incidence of side effect of women (4.4%) in study group was significant lower than that of women (13.0%) in control group (P<0.05), and the success rate of tocolytic theraphy of women (95.7%) in study group was significantly higher than that of women (82.6%) in control group (P<0.05). The rate of adverse events of women (13.6%) in study group had no significant difference when compared to that of women (14.0%) in control group (P>0.05). Conclusion: Compared to the conventional western medicine progesterone therapy, Baotai Decoction combined with low dose of progesterone can significantly modulate luteal phase hormone level, shorten the remission period of patients symptoms, decrease rate of side effect of drugs, and improve the success rate of tocolytic theraphy, so it is worthy of clinical using in pregnant women with threatened abortion caused by luteal phase defect .
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