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| Research of dosage form of microneedle sustained released gestodene before prescription |
| 1. Centre of Drug and Medical Polymer Materials, Nationals Research Institute for Family Planning, Beijing, 100081; 2. Graduate School of Peking Union Medical College |
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Abstract Objective: To achieve the slow releasing gestodene of microneedles for 7 days by increased the solubility and in vitro dissolution rate under solid dispersion technique, and to provide research evidence for designing dosage form of microneedle sustained released gestodene before prescription. Methods: The solid dispersion was prepared by the solvent evaporation method with PVPK30 as the carrier, and the in vitro dissolution characteristics of gestodene-PVPK30 solid dispersion was determined by IR spectra, Xray powder diffraction and DSC. And the in vitro transdermal release test was performed on the microneedles prepared by the gestodene solid dispersion. Results: The dissolution rate of gestodene was improved when it was dispersed in solid dispersion．The best proportion of solid dispersion was 1:4．The average release rate of the solid dispersion in the transdermal release test of gestodene sustainedrelease microneedles was about 23.97 μg/cm2, which was much greater than that of the drug whose average release rate was 448 μg/cm2. Conclusion: The solid dispersion can improve the dissolution rate of gestodene significantly, which can improve the drug release from microneedle delivery system.
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