|
|
|
| Efficacy and safety of mifepristone combined with misoprostol for termination of pregnancy between 16 and 24 weeks of gestation |
|
|
|
|
Abstract Objective: To explore the efficacy and safety of mifepristone combined with misoprostol for termination of pregnancy between 16 and 24 weeks of gestation. Methods: Women recruited were randomized to two groups: 53 in medical abortion group and 53 in ethacridine group. Routine surgical evacuation was only performed in ethacridine group after the expulsion of placenta. Results: The incidence of fetus expulsion was 94.3% in the medical group and 98.1% in the ethacridine group, showing no significant difference; The mean induction-to-abortion interval was (48.7±7.0) h and (38.5±9.4) h, showing significant difference in two groups; The uterine contraction-to-abortion time was (10.6±6.7) h and (14.2±9.0) h in two groups, showing significant difference；The incidence of surgical evacuation in medical group was 18.9% most of which was immediate evacuation. Conclusion: vaginal misoprostol combined with mifepristone without invasive procedures is effective and safe for termination of pregnancy between 16 and 24weeks of gestation.
|
|
|
|
|
|
|
|
|
