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| Improvement of pregnancy outcomes of frozen thawed embryo transfer cycle with GnRHa use followed by hormone replacement in patients with polycystic ovary syndrome |
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Abstract Objective: To explore the pregnancy outcome of frozen-thawed embryo transfer cycle with 3.75mg of GnRHa followed by hormone replacement in patients with polycystic ovary syndrome (PCOS). Methods: A total of 190 patients with PCOS seeking for frozen-thawed embryo transfer were divided into two groups. Women in group A were given hormone replacement (n=98) and those in group B used 3.75mg of GnRHa combined with hormone replacement (n=92) according to the endometrial preparation. The differences in implantation rate, pregnancy rate, miscarriage rate and reproductive hormone levels between the two groups were evaluated. Results: Compared with group A, women in group B achieved significantly higher pregnancy rate (70.6% vs. 51.0%, P<0.05), higher implantation rate (51.9% vs. 35.8%, P<0.05), and significantly lower luteinizing hormone level during the treatment. No significant differences were found between group A and group B in early abortion rate，ectopic pregnancy rate, multiple fetal rate and live birth rate（P all >0.05）. Conclusion: The hormone replacement after 3.75mg of GnRHa could improve PCOS frozen embryo transfer implantation rate and pregnancy rate.
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