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Abstract Objective: To compare the efficacy of intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF) among non-severe-male infertility women with poor ovarian response. Methods: A total of 246 IVF/ICSI-embryo transfer (ET) cycles of non-severe-male infertility women with poor ovarian response were divided into IVF group and ICSI group. The fertilization rate, cycle cancellation rate, high quality embryo rate, clinical pregnancy rate and early abortion rate were retrospectively analyzed between two groups. Then 246 IVF/ICSI-ET cycles were divided into A group (>35 to 40 years old) and B group (>40 years old ) according to the age of women. The fertilization rate, cycle cancellation rate, high quality embryo rate and clinical pregnancy rate were retrospectively analyzed between two groups. Finally indicators mentioned above were respectively compared between IVF and ICSI group according to the number of oocytes retrieved (one to three). Results: There were no significant differences in the fertilization rate, cycle cancellation rate, high quality embryo rate, clinical pregnancy rate and early abortion rate when compared in three ways (P all >0.05). Conclusion: ICSI can not improve the fertilization results and clinical outcomes in non-severe-male infertility women with poor ovarian response. In particular, the old age and low number of oocytes retrieved are not indications of ICSI.
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