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Abstract Objective: To observe the clinical effect of phloroglucinol in patients with prolonged incubation. Methods: Two hundred pregnant women were randomly divided into two groups: phloroglucinol group and control group. Women in phloroglucinol group were intravenous injected 80 mg of phloroglucinol, and those in the control group were treated by conventional obstetric therapy. And then the birth process, cervical opening time, duration of the second labor stage, amount of bleeding 2 hours after delivery, cervical edema rate, cervical laceration rate, cesarean section rate and incidence of neonatal complications were observed. Results: After the use of phloroglucinol, the cervical opening time was shorter than that of the control group ［(4.72±0.83) h vs. (6.43±1.12) h, P<0.05］. There was no significant difference in the duration of the second labor stage between the two groups ［(53.43±11.33) min vs. (55.21±1098) min, P>0.05］. The incidence of cervical edema in phloroglucinol group was significantly less than that of the control group (6% vs. 17%, P<0.05). And there were no significant differences in the incidence of cervical laceration (3% vs. 2%, P>0.05), the amount of bleeding 2 hours after delivery ［(209.5±67.7) ml vs. (213.4±54.9) ml, P>0.05］ and the incidence of neonatal complications (16% vs. 18%, P>0.05) between the two groups. In addition, the cesarean section rate in phloroglucinol group decreased significantly when compared with the control group (7% vs. 21%, P<0.05). Conclusion: The application of phloroglucinol in the incubation period of birth process could obviously accelerate the cervical opening speed, and reduce the incidence of cervical edema and cesarean section and be safe for no effects on the duration of the second labor stage, the amount of bleeding 2 hours after delivery, and the incidence of cervical laceration and neonatal complications .
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