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Abstract Objective: To explore the clinical effect of small dose of mifepristone combined with misoprostol in early pregnancy termination within a year after cesarean section. Methods: Totally 200 women with early pregnancy (gestational sac≤25 mm) within a year after cesarean section from January 2013 to December 2013 in Huai'an Maternal and Child Health Care Hospital was chosen as the research subjects, and randomly divided into two groups. Women in the control group (n=100) underwent suction evacuation guided by color Doppler ultrasound, while those in the observation group (n=100) were given small dose of mifepristone (75 mg) the night before and misoprostol (400 ug) sublingually 30 min before the operation. The occurrence rates of dilatation of the uterine neck, abdominal pain, amount of bleeding, artificial abortion syndrome, pregnancy residue and uterine perforation were observed. Results: The rate of dilatation of the uterine neck was 100%（100/100) in the control group and 10% (10/100) in the observation group. The rate of artificial abortion syndrome was 18% (18/100) in the control group and 6% (6/100) in the observation group. The rate of mild, moderate and severe abdominal pain were 80% (80/100), 14% (14/100), 6% (6/100) in the control group respectively, and 95% (95/100), 5% (5/100), 0 (0/100) in the observation group. In the control group, the amount of bleeding was (16.3±2.5) ml, while (12.3±2.1) ml in observation group, shouing a significant difference (P＜0.05). The rate of uterine perforation was 2% (2/100) in the control group, and 0 (0/100) in the observation group (P﹥0.05). There was no significant difference in the pregnancy residue between two groups (P﹥005). Conclusion: Small dose of mifepristone combined with sublingual misoprostol before suction evacuation guided by color Doppler ultrasound in early pregnancy termination within a year after cesarean section is relatively safe, effective and would be worth popularizing.
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