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Abstract Objective: To explore the clinical effect of lymphocyte active immunotherapy on repeated spontaneous abortion women with blocking antibody negative. Methods: From January to June 2012, 149 patients with repeated spontaneous abortion were recruited, whose blocking antibody negative was confirmed and received the active immune therapy in Ankang traditional Chinese medicine hospital. The peripheral venous blood of the patients 'husband was regarded as the target antigen, and performed the active lymphocyte immune therapy. Meanwhile, the repeated spontaneous abortion women who never experienced any immune therapy were included in control group. The lymphocyte factor expression was detected and pregnancy outcome was observed. Results: The study showed that the rate of pregnancy in trial group and in control group was 42.1% and 21.6%, respectively, and there was statistically significant difference (P < 0.05). The rate of spontaneous abortion again was 25.0%, 58.3%, respectively, and there was statistically significant difference (P < 0.05). After active immunotherapy, the level of lymphocyte factor (IL-2, IFN-gamma, IL-4, IL-6) and the effectives of blocking the CD4+and CD8 + were significantly higher than those of control group (P< 0.05). After immunotherapy, the level of lymphocyte factor expression (IL-2, IFN-gamma, IL-4, IL-6) in blocking antibody positive patients were significantly higher than that of blocking antibody negative patients (P < 0.05), and numbers of CD4 + and CD8 + were significantly higher in the blocking antibody positive patients, and there was statistically significant difference (P< 0.05). Conclusion: The active immunotherapy can improve pregnancy rate, reduce the risk of spontaneous abortion. The effective of immunotherapy of repeated spontaneous abortion patients with blocking antibody negative is remarkable, and the efficiency of clinical treatment is reliable.
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