Objective: To investigate the effects of resveratrol regulating lipid metabolism disorder of rats with gestational diabetes. Methods: 60 rats with gestation for five days were intraperitoneal injected streptozotocin(STZ) 35mg/kg to make gestational diabetic model. All of the rats were randomly divided into five groups and there were 12 rats in each group, which including no any treated gestational diabetic model control group, resveratrol(60, 120 or 240 mg/kg) treated groups and Metformin hydrochloride 200 mg/kg treated group. Except that, 12 rats with gestation for five days into normal gestation control group and 12 non-pregnant rats into another control group. The level of plasma glucose and insulin were determined before the drugs treatment and 7, 14 days after treatment. After two weeks of treatment, the body weight was detected , the content of TC, TG, LDL C, HDL C in serum were detected, and the level of Leptin, Adiponectin, Chemerin, TNFα, IL6 in plasma were also detected. Results: Compared with normal pregnant rats, the level of plasma glucose of rats and the body weight of rats in gestational diabetic model group were significantly increased and the level of insulin was significantly decreased；the level of TC, TG, LDL C were significantly increased and the HDL C was significantly decreased; the level of Leptin, Chemerin, TNFα, IL6 in plasma were significantly increased and the Adiponectin was significantly decreased. Compared with the rats with gestational diabetic in no resveratrol treated group, the content of TC and TG, the level of plasma glucose, the content of LDL C, the level of Leptin, Chemerin, TNFα, IL6 in plasma and the body weight of rats in resveratrol treated groups were significantly decreased, but the level of insulin, the content of HDL C and the level of Adiponectin in plasma were significantly increased. And all of above changes complied with dose dependent of resveratrol. Compared with the Metformin hydrochloride treated group, the level of insulin and the Adiponectin of rats in resveratrol 240 mg/kg treated group was significantly increased, the content of TC, TG, LDL C were significantly decreased, and the level of Leptin, Chemerin, TNFα,and IL6 in plasma were also significantly decreased. Conclusion: Resveratrol improves insulin secretion, lowering blood sugar and body weight of rats, and can regulate plasma lipid, Leptin, Chemerin, TNFα, IL6 and Adiponectin, which is a dose-dependent effect. Resveratrol 240 mg/kg treatment has higher effectiveness than that of Metformin hydrochloride treatment.