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Abstract Objective: To evaluate the safety and efficacy of TCu220C intrauterine device (IUD), and to compare the effect of TCu220C with other copper bearing IUDs for providing scientific evidence for safe contraception. Method: English databases including PubMed, EMBASE, CENTRAL, POPLINE, websites including Current Controlled metaRegister, FDA, WHO and related enterprises, and Chinese databases including CBMdisc, CMCI, CNKI, VIP and Wanfang were searched. The inclusion and exclusion criteria were set according to the PICOS principle. The literatures were imported into the endnote X7 software of document management, and repeat literatures in the database were excluded. The data was inputted by EpiData 3.1, and pool trial proportion with weight and derive RR and 95% confidence interval of meta-analysis was conducted by RevMan 5.3.3 and OpenMeta Analyst. The criteria on assessing risk of bias were used for methodological quality of literatures. The GRADE system was used for grading of evidence quality. Search results: 7097 Chinese and 629 English literatures were preliminarily retrieved, 28 studies involving TCu220C IUD RCTs and quasi RCTs ultimately were recruited, including 31 literatures formally published from 1983 to 2014, which was 7 English and 24 Chinese literatures. There were a total of 43239 women, including 15794 IUD users in TCu220C group and 27445 IUD users in control group (using other IUD). Results: Comparing overall effect of domestic group with abroad group in TCu220C IUD users, there were significant differences of the total termination rate, using related discontinuation rate, termination rate for medical reason removal, side effects rate, while no significant differences of pregnancy rate and expulsion rate. Meta analysis results also showed that the risk of expulsion of TCu220C IUD inserted after artificial abortion increased. The risk of medical removal of TCu220C IUD inserted after artificial abortion or lactation significantly increased (mainly for bleeding and pain). Conclusions: Although the use of the TCu220C IUD is affected by the inserted periods and the different users, it is still selectively used among the appropriate women.
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