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Abstract Objective: To explore the clinical effect of the traditional chinese medicine treatment Based upon Differentiation of Syndromes in patients with gestational diabetes mellitus(GDM). Methods: 120 cases of gestational women with GDM who received antenatal care in Guangdong Women and Children Hospital were recruited. According to outcomes of physical assessment of these women by Chinese medicine, all the women were divided into balance type group(n=60) or imbalance type group(n=60). Serum levels of glucose and lipid metabolism indexes were determined for all women. All women were given dietary guidance and chinese medicine treatment based on syndrome differentiation. Glucose and lipid metabolism indexes were analyzed before and after intervention, and the effects of traditional chinese medical were evaluated. Results: Levels of fasting plasma glucose(FPG), fasting insulin(FINS), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) and total cholesterol(TC) in patients with imbalance type was higher than that of patients with balance type, but the levels of Visfatin, high density lipoprotein cholesterol(HDL-C), apolipoprotein A(ApoA) and ApoA/ApoB was lower than that of patients in the balance type group, the differences was statistically significant(P<0.05). After the traditional chinese medicine intervention, 42 cases of gestational women with imbalance type were changed into balance type. The levels of FPG, FINS, glycosylated hemoglobin A1c (HbA1c), TG, TC, LDL-C and apolipoprotein B(ApoB) in the pregnant women with imbalance type were significantly lower than that of pretherapy(P<0.05). However, the levels of Visfatin, HDL-C, ApoA and ApoA/ApoB were higher than that of pretherapy(P<0.05). Conclusion: Most of pregnant women with GDM are imbalance types. The traditional chinese medicine treatment based on syndrome differentiation is effective in treating GDM, which can improve the metabolism of glucose and lipid disorders.
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