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Abstract Objective: To explore the relationship between chromosome karyotyping and male infertility. Method: Chromosome karyotyping and semen analysis were carried out in 5437 infertile men from September 2011 to October 2013 at Shenzhen zhongshan urology hospital. The patients were assigned to three groups according to their semen parameters. Chromosome karyotyping was performed for all patients in three groups. Results: The chromosome abnormality rate of patients in azoospermia group was 8.33%, which was significantly higher than that of in normal semen parameters group(1.02%). The chromosome abnormality rate of patients in oligo- or astheno- or teratozoospermia group was 2.84%, which was also higher than that of in normal semen parameters group. The incidence of chromosomal polymorphisms did not significantly differ in patients among the three groups. Conclusion: Chromosomal abnormality is one of the important causes of male infertility, while chromosome polymorphism does not cause spermatogenesis failure. Chromosome Karyotyping should be carried out in all patients with male infertility.
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